July 20 - 22, 2017

Venue:

Hanse-Wissenschaftskolleg
Lehmkuhlenbusch 4
27753 Delmenhorst

Organizers:

• Prof. Dr. Christiane Richter-Landsberg
  Carl von Ossietzky Universität Oldenburg
• Prof. Dr. Illana Gozes
  Tel Aviv University, Israel

July 20 - 22, 2017

Venue:

Hanse-Wissenschaftskolleg
Lehmkuhlenbusch 4
27753 Delmenhorst

Organizers:

• Prof. Dr. Christiane Richter-Landsberg
  Carl von Ossietzky Universität Oldenburg
• Prof. Dr. Illana Gozes
  Tel Aviv University, Israel

With the advances in medicine and extended longevity, neurodegenerative diseases become more prevalent and present major unmet medical needs with suffering to the patients, their families and society as a whole. The aim of the HWK Molecular Neurodegeneration Symposium is to bring together experts on the molecular basis of neurodegeneration, paving the path to the identification of new molecular targets for early diagnosis, prevention and intervention. The venue is excellent to promote formal and informal exchange of ideas that will lead to further collaborations and new findings. Neuroscience students from surrounding universities will present posters and take part in the discussions, opening new horizons to the next generation scientists and promoting research in Lower Saxony, Germany and worldwide. A special session will be devoted to industry connections, trying to translate basic findings to practical diagnostic kits and drug candidates.

With the advances in medicine and extended longevity, neurodegenerative diseases become more prevalent and present major unmet medical needs with suffering to the patients, their families and society as a whole. The aim of the HWK Molecular Neurodegeneration Symposium is to bring together experts on the molecular basis of neurodegeneration, paving the path to the identification of new molecular targets for early diagnosis, prevention and intervention. The venue is excellent to promote formal and informal exchange of ideas that will lead to further collaborations and new findings. Neuroscience students from surrounding universities will present posters and take part in the discussions, opening new horizons to the next generation scientists and promoting research in Lower Saxony, Germany and worldwide. A special session will be devoted to industry connections, trying to translate basic findings to practical diagnostic kits and drug candidates.

• Molecular aspects in neurodegeneration

• The cytoskeleton and associated proteins

• Microtubules and brain disease

• Glial cells and disease

• Molecular aspects in neurodegeneration

• The cytoskeleton and associated proteins

• Microtubules and brain disease

• Glial cells and disease

• Annie Andrieux (Grenoble, France)
• Peter Baas (Philadelphia, USA)
• Graziella Cappeletti (Milano, Italy)
• Sandra Cardoso (Coimbra, Portugal)
• A. Claudio Cuello (Montreal, Canada)
• Illana Gozes (Tel Aviv, Israel)
• Helmut Kettenmann (Berlin, Germany)
• Matthias Kneussel (Hamburg, Germany)
• Karl-Wilhelm Koch (Oldenburg, Germany)
• Eva-Maria Krämer-Albers (Mainz, Germany)
• Maria Magdalena Magiera (Paris, France)
• Sebastian Maurer (Barcelona, Spain)
• Mami Noda (Fukuoka, Japan)
• Christiane Richter-Landsberg (Oldenburg, Germany)
• Kristian Strømgaard (Copenhagen, Denmark)

• Annie Andrieux (Grenoble, France)
• Peter Baas (Philadelphia, USA)
• Graziella Cappeletti (Milano, Italy)
• Sandra Cardoso (Coimbra, Portugal)
• A. Claudio Cuello (Montreal, Canada)
• Illana Gozes (Tel Aviv, Israel)
• Helmut Kettenmann (Berlin, Germany)
• Matthias Kneussel (Hamburg, Germany)
• Karl-Wilhelm Koch (Oldenburg, Germany)
• Eva-Maria Krämer-Albers (Mainz, Germany)
• Maria Magdalena Magiera (Paris, France)
• Sebastian Maurer (Barcelona, Spain)
• Mami Noda (Fukuoka, Japan)
• Christiane Richter-Landsberg (Oldenburg, Germany)
• Kristian Strømgaard (Copenhagen, Denmark)

Monday July 20, 277

08:45 – 09:20  Registration and Poster Mounting
09:20 – 09:30  Welcome address
                           Special lecture
                           Chair: Illana Gozes (Tel Aviv, Israel)
09:30 – 10:10  Claudio Cuello (Montreal, Canada):
                           A nerve growth factor dysmetabolism in Alzheimer’s and in
                           Down Syndrome
10:10 – 12:40  SESSION 1: Glial cells and disease
                           Chair: Christiane Richter-Landsberg (Oldenburg, Germany)
10:10 – 10:50  Helmut Kettenmann (Berlin, Germany):
                           Role of microglia in pathology
10:50 – 11:20  Coffee break
11:20 – 12:00  Mami Noda (Fukuoka, Japan):
                           Microglial dysfunction and neuronal damage in neurodegeneration.
12:00 – 12:40  Eva-Maria Krämer-Albers (Mainz, Germany):
                           The role of exosomes in neuron-glia communication and neuroprotection
12:40 – 14:00  Lunch
14:00 – 15:30  Poster session
15:30 –16:40  SESSION 2: Cytoskeleton and beyond
                          Chair: Annie Andrieux (Grenoble, France)
15:30 - 16:10  Matthias Kneussel (Hamburg):
                          Cytoskeletal transport and anchoring in the regulation of
                          synaptic trafficking
16:10 - 16:25   Poster talk 1: Amrit Mudher
16:25 – 16:40  Poster talk 2: Frank Kooy
16:40 – 17:10  Coffee break
                           Special Lecture
                           Chair: Ulrike Janssen-Bienhold (Oldenburg, Germany)
17:10 – 17:50  Karl Koch (Oldenburg, Germany):
                           Molecular mechanisms of retinal degeneration
18:00                Dinner

Tuesday July 21, 277

09:00 – 12:10  SESSION 3: Microtubules and brain disease
                           Chair: Claudio Cuello (Montreal, Canada) and
                           Marie-Francoise Suaud-Chagny (Bron, France)
09:00 – 09:40  Peter Baas (Philadelphia, USA):
                           Microtubules: Loss-of-function and gain-of-function mechanisms
                          contributing to neurodegeneration
09:40 – 10:20  Illana Gozes (Tel Aviv, Israel):
                           Cytoskeleton as drug target for neuroprotection
10:20 – 10:50  Coffee break
10:50 – 11:30  Annie Andrieux (Grenoble, France):
                          Microtubule dysfunctions in neuro -degenerative -psychiatric diseases
11:30 – 12:10  Graziela Cappelletti (Milan, Italy):
                           Looking at microtubule dysfunction in toxin- and gene-based models of
                           Parkinson's disease
12:10 – 13:30  Lunch
13:30 – 15:30  Poster Session
15:30 – 18:00  SESSION 4: Molecular aspects in neurodegeneration:
                           The cytoskeleton and associated proteins
                           Chair: Peter Baas (Philadelphia, USA)
15:30 – 16:10  Sebastian Maurer (Barcelona, Spain):
                           Microtubule plus end tracking and dynamic instability are
                           mechanistically linked
16:10 – 16:50  Magdalena Magiera (Paris, France):
                           Microtubule posttranslational modifications
16:50 – 17:20  Coffee break
17:20 – 18:00  Christiane Richter-Landsberg (Oldenburg, Germany):
                           Protein aggregate formation in oligodendrocytes: The cytoskeleton and
                           autophagy at the intersection of neuroprotection and
                           neurodegeneration.
18:00                Dinner
20:00                Social event at HWK

Wednesday July 22, 277

09:00 – 10:20  SESSION 5: Mechanisms to clinical trials
                           Chair: Markus Kipp (München, Germany)
09:00 – 09:40  Sandra Morais Cardoso (Coimbra, Portugal): Mitochondria:
                           On the road to neurodegeneration in sporadic Alzheimer’s disease
09:40 – 10:20  Kristian Stromgard (Copenhagen, Denmark):
                           Translational medicine and drug design
10:20 – 10:45  Coffee break
                           Poster talks
                           Chair: Ephraim Yavin (Rehovot, Israel)
10:45 – 11:00  Poster talk 3: Benedict Niewidok
11:00 – 11:15  Poster talk 4: Janina Leyk
11:15 – 11:30  Poster talk 5: Felix Bulcke
11:30 – 11:45  Poster talk 6: Farina Vocke
11:45 – 12:00  Poster talk 7: Tina Schlüter
12:00 – 12:10  Poster prize and closing remarks
12:10 – 13:30  Lunch
                          Departure

Monday July 20, 277

08:45 – 09:20  Registration and Poster Mounting
09:20 – 09:30  Welcome address
                           Special lecture
                           Chair: Illana Gozes (Tel Aviv, Israel)
09:30 – 10:10  Claudio Cuello (Montreal, Canada):
                           A nerve growth factor dysmetabolism in Alzheimer’s and in
                           Down Syndrome
10:10 – 12:40  SESSION 1: Glial cells and disease
                           Chair: Christiane Richter-Landsberg (Oldenburg, Germany)
10:10 – 10:50  Helmut Kettenmann (Berlin, Germany):
                           Role of microglia in pathology
10:50 – 11:20  Coffee break
11:20 – 12:00  Mami Noda (Fukuoka, Japan):
                           Microglial dysfunction and neuronal damage in neurodegeneration.
12:00 – 12:40  Eva-Maria Krämer-Albers (Mainz, Germany):
                           The role of exosomes in neuron-glia communication and neuroprotection
12:40 – 14:00   Lunch
14:00 – 15:30  Poster session
15:30 –16:40   SESSION 2: Cytoskeleton and beyond
                           Chair: Annie Andrieux (Grenoble, France)
15:30 - 16:10  Matthias Kneussel (Hamburg):
                          Cytoskeletal transport and anchoring in the regulation of
                          synaptic trafficking
16:10 - 16:25  Poster talk 1: Amrit Mudher
16:25 – 16:40  Poster talk 2: Frank Kooy
16:40 – 17:10  Coffee break
                           Special Lecture
                           Chair: Ulrike Janssen-Bienhold (Oldenburg, Germany)
17:10 – 17:50  Karl Koch (Oldenburg, Germany):
                           Molecular mechanisms of retinal degeneration
18:00                 Dinner

Tuesday July 21, 277

09:00 – 12:10   SESSION 3: Microtubules and brain disease
                            Chair: Claudio Cuello (Montreal, Canada) and
                            Marie-Francoise Suaud-Chagny (Bron, France)
09:00 – 09:40   Peter Baas (Philadelphia, USA):
                            Microtubules: Loss-of-function and gain-of-function mechanisms
                            contributing to neurodegeneration
09:40 – 10:20  Illana Gozes (Tel Aviv, Israel):
                           Cytoskeleton as drug target for neuroprotection
10:20 – 10:50  Coffee break
10:50 – 11:30   Annie Andrieux (Grenoble, France):
                           Microtubule dysfunctions in neuro -degenerative -psychiatric diseases
11:30 – 12:10  Graziela Cappelletti (Milan, Italy):
                           Looking at microtubule dysfunction in toxin- and gene-based models of
                           Parkinson's disease
12:10 – 13:30  Lunch
13:30 – 15:30  Poster Session
15:30 – 18:00  SESSION 4: Molecular aspects in neurodegeneration:
                           The cytoskeleton and associated proteins
                           Chair: Peter Baas (Philadelphia, USA)
15:30 – 16:10  Sebastian Maurer (Barcelona, Spain):
                           Microtubule plus end tracking and dynamic instability are
                           mechanistically linked
16:10 – 16:50  Magdalena Magiera (Paris, France):
                           Microtubule posttranslational modifications
16:50 – 17:20  Coffee break
17:20 – 18:00  Christiane Richter-Landsberg (Oldenburg, Germany):
                           Protein aggregate formation in oligodendrocytes: The cytoskeleton and
                           autophagy at the intersection of neuroprotection and
                           neurodegeneration.
18:00                Dinner
20:00                Social event at HWK

Wednesday July 22, 277

09:00 – 10:20  SESSION 5: Mechanisms to clinical trials
                           Chair: Markus Kipp (München, Germany)
09:00 – 09:40  Sandra Morais Cardoso (Coimbra, Portugal): Mitochondria:
                           On the road to neurodegeneration in sporadic Alzheimer’s disease
09:40 – 10:20   Kristian Stromgard (Copenhagen, Denmark):
                           Translational medicine and drug design
10:20 – 10:45  Coffee break
                          Poster talks
                          Chair: Ephraim Yavin (Rehovot, Israel)
10:45 – 11:00  Poster talk 3: Benedict Niewidok
11:00 – 11:15  Poster talk 4: Janina Leyk
11:15 – 11:30  Poster talk 5: Felix Bulcke
11:30 – 11:45  Poster talk 6: Farina Vocke
11:45 – 12:00  Poster talk 7: Tina Schlüter
12:00 – 12:10  Poster prize and closing remarks
12:10 – 13:30  Lunch
                          Departure